The CD24 antigen, which has a molecular weight of 35-45 kDa, is a glycosyl phosphatidylinositol (GPI)-anchored surface molecule. The weight of an edge represents the . Molecular Weight: 290.10. Formulation: Lyophilized from a 0.2 m filtered solution in PBS. Tian RR, Zhang MX, Liu M, Fang X, Li D, Zhang L, Zheng P, Zheng YT, Liu Y. CD24Fc protects against viral pneumonia in simian immunodeficiency virus . RESEARCH USE For research use only, not for use in diagnostic procedures. Positive Controls: M1 whole cell lysate: sc-364782, mouse spleen extract: sc-2391 or CTLL-2 cell lysate: sc-2242. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Soluble CD24 (CD24Fc) blunts the broad inflammatory response induced by damage-associated molecular patterns via binding to extracellular high mobility group box 1 and heat shock proteins, as well as regulating the downstream Siglec10-Src homology 2 domain-containing phosphatase 1 pathway. Success from the first experiment - confirmed specificity . Match Criteria: Keyword. Studies have shown that CD24 functions in the regulation of B-cell apoptosis, leukocyte signal transduction, and leukocyte adhesion. ABSTRACT CD24 is a signal transducing molecule on the surface of most human B cells, murine immature T cells, myeloid and erythroid lineage cells. Since it is highly glycosylated, the apparent molecular weight of CD24 could be variable, ranging from 30 kDa to 70 kDa. Low molecular weight heparin did not have an effect on K1735 melanoma tumor growth either. Dose response curve for Anti-CD24 Antibody, hFc Tag with the EC50 of 22.1ng/ml determined by ELISA. CD24 associates with high mobility group box 1, heat shock protein 70, and heat shock protein 90; negatively regulates their stimulatory activity; and inhibits nuclear factor B (NF-B) activation. , , . CD markers See testing image for detail. CD24 is overexpressed in ECs compared with other GCT entities and can be associated with an undifferentiated pluripotent cell fate. CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS. In CD44+/CD24- and original MCF7 cells, Tunicamycin (2 g/mL; 24 hours; CD44+/CD24- and original MCF7 cells) treatment increases the spliced XBP-1, ATF6 nuclear translocation level and CHOP protein expression. codes for CD24 which has a heterogeneous molecular weight ranging from 30 to 70 kDa. It is low in endotoxin; Less than 1.0 EU/g protein (determined by LAL method). Anti-CD44 antibody [EPR18668] (ab189524) Research with confidence - consistent and reproducible results with every batch. Apparent Molecular Weight ~4.2 kDa, on SDS-PAGE under reducing conditions. CD24 (CD24 Molecule) is a Protein Coding gene. Placental CD24 had an apparent molecular weight of 30-70 kDa consistent with its high degree of N- and O-linked glycosylation. CD24. Long-term and scalable supply - powered by recombinant technology for fast production. By immunohistochemistry, it is widely detected in many solid tumors, such as breast cancers, genital system cancers, digestive system cancers, neural system cancers and so on. . The expression of other CSC makers such as CD133 and CD24 was not reported. Molecular Weight. Add the test sample to each well, and add 5 L of Pre-stained Protein Marker (Cat# E-BC-R273)to a reserved well in order to verify the target molecular weight and the extent of membrane transfer.Add Electrophoresis Buffer ( Cat# E-BC-R331) and start electrophoresis. cd24 is a small, heavily-glycosylated, mucin-like glycosylphosphatidylinositol-anchored surface protein (6). Conclusion (Ref: Akihiko Sano, MD., 2009) Protocols Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Positive Controls: CD24 (h): 293T Lysate: sc-116926, HeLa whole cell lysate: sc-2200 or A549 cell lysate: sc-2413. It is expressed on mature granulocytes and on a variety of epithelial cell types. Metabolici. Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene. CD24 is regulated by SOX2 and their levels are correlated in metastatic melanoma patient samples. Since it is highly glycosylated, the apparent molecular weight of CD24 could be variable, ranging from 30 kDa to 70 kDa. View detailed CD24 antibody specifications by linking to the specific product blocks. CD24 was first described for its role in blocking B lymphocyte (B cell) development. Please contact us for any concerns or special requirements. Purification. molecular and histoclinical parameters that classify breast cancer in several distinct subtypes: basal, luminal A and B, . The CD24 antigen is a glycosyl-phosphatidylinositol-linked membrane sialoglycoprotein, with a molecular weight of 35-45 kDa. EXO-CD24 may represent a new therapeutic opportunity to overcome the devastating effect of COVID-19 and beyond. 14 In the beginning of . Express System: Expi293: CD24 Protein LS-G138207 is a Recombinant Rat CD24 produced in HEK 293 Cells Met1-Cys55 with Fc, C-terminus tag(s). Show all. It is a member of a family that also includes HSA and CD52. 2018 Sep;157:9-17. doi: 10.1016/j.antiviral.2018.07.004. CD24 is present on B cells, from the pre-B to the mature B cell stage, but not on plasma cells. The present study found that CD24 is highly expressed in NF2/16-DKO cell clones and human MPM tissues, highlighting it as a potential diagnostic and therapeutic target for MPM. 10-13 Biochemical analysis showed that the antigen migrated at a molecular mass of 40 to 70 kDa in SDS-PAGE. CD24, also known as heat-stable antigen in the mouse, is a glycosylphosphatidylinositol-anchored membrane protein of heterogeneous molecular weight ranging from 30 to 70 kDa ( 1 ). 2 CD24 is expressed on preB lymphocytes, neutrophils, and certain epithelial cells but not on normal Tcells, Select CD24 antibodies from monoclonal antibodies listed below. . 1.According to the molecular weight of the target protein, prepare 0% separation gel. CD24 Antibody (MA5-11828) in WB Western blot analysis of CD24 was performed by loading 25 g of MCF-7 (Lane 1) and Daudi (Lane 2) cell lysates and a molecular weight protein ladder onto an SDS polyacrylamide gel. CD24 is a cell surface protein, which is anchored on the external side of the plasma membrane. Stable for one year from the date of Among its related pathways are L1CAM interactions and Nervous system development . General notes This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free production For more information see here. Therefore, CD24 as the novel immunotherapy target, is a newly discovered "don't eat me" signaling protein, like the popular molecular CD47. Molecular Weight 150 kDa: Storage The antibody solution should be stored at the stock . Antiviral Res. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns). CD24 is one of the earliest expressed proteins during human B cell maturation, being present at the late pro-B cell stages alongside surface markers such as CD21 and cytoplasmic heavy chains (1, 2).CD24 is a highly glycosylated protein which is glycosyl-phosphatidylinositol-anchored (GPA) but can be localized to lipid rafts on the plasma membrane of B cells (). Rat CD24 cDNA is homologous to murine and human Clonality Application Species Reactivity Citations SDS; ZRB1564: . Diseases associated with CD24 include Erythroleukemia and Multiple Sclerosis . RESEARCH USE For research use only, not for use in diagnostic procedures. Primary Antibodies are guaranteed for 1 year from date of receipt. ts expression is upregulated in i -10). The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. Gastric cancer is a highly malignant tumor. CD24 Antibodies Santa Cruz Biotechnology, Inc. offers a broad range of CD24 antibodies. CD133, CD44, CD24, CDCP1 and CXCR4 are five cell surface antigens whose expression is thought to indicate stem cell like properties. Human. Milli-Mark Anti-CD24-FITC Antibody, clone SN3 Detect CD24 using this Milli-Mark Anti-CD24-FITC Antibody, clone SN3 validated for use in FC. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. Effective down-regulation of CD24 was associated with a short- term increase in permeability of the epithelial monolayer to low molecular weight dextran (Figure 8). CD44 is a type I transmembrane glycoprotein which binds to its ligands like MMPs, growth factors, cytokines and hyaluronan and subsequently activates RTKs through pathways like Src/FAK, PI3K/AKT and HGF/c-Met to trigger cell proliferation and survival signals for inducing stemness. CD24 is a small, glycophosphatidylinositol-anchored cell surface receptor with a diverse array of functions; when adaptive immunity, inflammation, autoimmunity and cancer are just some of them. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid. G7mAb specifically detected the recombinant human CD24 (CD24-Fc) but not the unrelated recombinant protein Fc. The protein also contributes to a wide range of downstream signaling networks and . Molecular Weight 8 kDa Gene ID . In high-grade NHL (Kiel classification) the absence of CD38 or presence of CD24 on tumor cells correlated with a higher degree of disease-free survival . . (A) Western blot assay of CD24 (CD24-Fc) or Fc detected by G7mAb. (B) Friguet. The apparent molecular weight of CD24 varies considerably among cell types and also within each cell type, depending on its developmental stage due to differences in glycosylation pattern (for references, see Refs. Formulation Lyophilized from sterile PBS, pH 7.4. it contains a small protein core of only 27 amino acids with varying levels of potential o-linked glycosylation, and n-which leads to a molecular weight range between 38 and 70 kda (6). 29.9 kDa. The binding of CD24 and Siglec-10 could inhibit phagocytosis of tumor cells by macrophages. We report that CD24-deficient mice exhibit increased susceptibility to danger- but not pathogen-associated molecular patterns. The CD44+CD24- . a Cell proliferation assessed as indicated by CCK8 assay.. The mature protein is only 27 to 30 amino acids long, and most of the molecular weight of the protein consists of extensive N- and O-linked glycosylation. The third category of DAMPs is low molecular weight adjuvants highly concentrated in the cytosol. The Cell line section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Molecular Weight: Human CD24 Protein has a predicted MW of 5.0 kDa. CD24 molecule. . Introduction. Expression System. CD24 is expressed by erythrocytes, granulocytes, monocytes, lymphocytes, and dendritic cells. Select appropriate CD24 antibodies for your research by isotype, epitope, applications and species reactivity. We aimed to determine the expression of CD24 in plasma, exosomes and ovarian tissue samples of serous ovarian cancer patients. The influence of the molecular weight on CD44-hyaluronan interactions and on the immune response. Cross-linking of CD24 can induce increased intracellular Ca++ in mature B lymphocytes (Turni, 2002). The CD24 antigen is a glycosyl-phosphatidylinositol-linked membrane sialoglycoprotein, with a molecular weight of 35-45 kDa. This occurs at . Synonyms. We isolated rat CD24 gene from em- bryonic brain cDNA library and characterized the gene expression during rat embryogenesis. CD24 is a highly glycosylated protein with a molecular weight of 30-70 kDa that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI) anchor. Molecular weight (Da) 3128.18 Theoretical pI 5.72 Recombinant CD24 Protein Feature CD24 Protein, Human, Recombinant (hFc Tag) 11030-H02H High Purity > 92 % as determined by SDS-PAGE Low Endotoxin < 1.0 EU per g of the protein as determined by the LAL method All Recombinant CD24 protein TF and PAR-4 expression was similar in the three cell lines. Molecular Weight of CD24: 35-45 kDa. characterized breast cancers gives weight to their conclusions. CONJUGATE: Unconjugated TESTED APPLICATIONS: WB APPLICATION NOTE: WB: 1:500 - 1:1000 POSITIVE CONTROL 1: Raji POSITIVE CONTROL 2: Raji+PNGaseF PREDICTED MOLECULAR WEIGHT: Observed: 45kDa CD24 is a two-chain glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed at multiple stages of B-cell development, beginning with the bone marrow pro-B-cell compartment and continuing through mature, surface Ig positive B-cells. HEK 293 Cells. All Photos (1) The Metabolic section enables exploration of protein function and tissue-specific gene expression in the context of the most curated human metabolic network. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. In humans, the CD44 antigen is encoded by the CD44 gene on chromosome 11. Description SDS Pricing; SML0223: 98% (HPLC) Expand. Hide. (a) Validation of SOX2 overexpression (OE) in A375 cells by qPCR showing relative . Molecular Weight of CD24: 35-45 kDa. Synonym(s): Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen. CD24 did not interact with Siglec-3 or Siglec-5. Fibrin content of the tumors was not affected by LMWH. EDTA-sensitive CD24-Siglec-10 interaction via the terminal sialic acid glycan residues of CD24 was observed. . . we present evidence that CD44v3 immunoexpression and CD44v3+/CD24- immunophenotypes could give prognostic information associated with unfavorable clinical outcomes. CD24 STORAGE Store at 4 C, **DO NOT FREEZE**. In the tested cell lines, levels of EpCAM and CD24 markers helped to distinguish ovarian cancer exosomes from exosomes derived from benign cells. (Ref: Akihiko Sano, MD., 2009) Protocols Standard Protocols crc (7 The diversity of CD24 glycosylation may be partly responsible for Molecular Weight: 32.7 kD . Journal: Molecular Therapy Article Title: Preclinical Corrective Gene Transfer in Xeroderma Pigmentosum Human Skin Stem Cells doi: 10.1038/mt.2011.233 Figure Lengend Snippet: Restoration of normal DNA repair capacity in vivo . 2011; 156:231-238. Protein length: The recombinant human CD24 consists of 270 amino acids and predicts a molecular mass of 29.7 KD. Formulation. Electrophoresis. Indeed, about 50% of the 27-31 amino acids in mature CD24 protein are potential anchors for either O- or N-linked oligosaccharides [2, 27]. Here, we show that promotion or inhibition of neurite outgrowth of cerebellar or dorsal root ganglion neurons, respectively, induced by the mucin-type adhesion molecule CD24 depends on 2,3-linked sialic acid and Lewisx present on glia . CD24 (CD24 Products) Synonyms CD24A, Cd24a, CD24 molecule, CD24, Cd24 Background Description: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. In this study, we deciphered the molecular and (epi)genetic mechanisms regulating expression of CD24, a highly glycosylated signaling molecule upregulated in many cancers. DOI: 10.1016/j.jbiotec.2019.03.018 Abstract CD24 is a small molecular weight cell-surface protein and an independent marker for poor prognosis in the different type of cancers. STORAGE Store at 4 C, **DO NOT FREEZE**. CD24 is a cell adhesion molecule. Compare Product No. Studies have shown that CD24 functions in the regulation of B-cell apoptosis, leukocyte signal transduction, and leukocyte adhesion. Because of the tendency of CD24 to be expressed on . 3 cd24 protein isolated from different tissues or cell types has different molecular. Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. Activity: Immobilized Human CD24 VLP at 0.5g/ml (100l/Well) on the plate. Our data suggest that the expression of CD24 as detected by immunohistochemistry is a new independent molecular marker for shortened survival time of patients with epithelial ovarian carcinomas. These observations suggest that post-translational modifications of CD24 play an important functional role. CD133 is a five-transmembrane domain antigen with a molecular weight of 120 kDa [ 9] and is found on stem-like cells of various tissues and cancers like pancreatic, prostate, kidney and colorectal cancer [ 10 ]. It is thought to have an essential role in cell differentiation, and is also expressed in cells involved in the immune system, such as B-lymphocytes, where it positively regulates the proliferation of activated T cells. - Find MSDS or SDS, a COA, data sheets and more information. The mature protein is only 27 to 30 amino acids long, and most of the molecular weight of the protein consists of extensive N- and O-linked glycosylation. Compare Product No. Source Species. CD44 (+)/CD24 (-) phenotype may be an important factor for malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma. Although carbohydrates have been implicated in cell interactions in the nervous system, the molecular bases of their functions have remained largely obscure. Epub 2018 Jul 3. . As a secondary metabolite of lichen, Atranorin has a variety of biological effects, such . EXO-CD24 is a novel platform that helps normalize immune activity. CD24 has the constitutive function of maintaining expression of selected genes encoding tight junction components associated with a marginal barrier function of epithelial monolayers. Cross-linking of CD24 can induce increased intracellular Ca++ in mature B lymphocytes (Turni, 2002). CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1. 45kDa. CD24 is also known as the heat-stable antigen (HSA) 42. Function. It is expressed on mature granulocytes and on a variety of epithelial cell types. It is a member of a family that also includes HSA and CD52. CD24 is present on B cells, from the pre-B to the mature B cell stage, but not on plasma cells. Plasma cell expression is very low or negative. CD24 gene and protein expression is highly dynamic in response to cellular differentiation and stimulation in a cell-specific manner. This data sug- gested that CD24 maintains a minimal barrier function in un-stimulated cells. Predicted Molecular Weight. EXO-CD24 leads to inhibition of tissue injury-driven inflammation without interfering with pathogen-induced immune activation. CD24-201 ENSP00000475625 ENST00000606017: P25063 [Direct mapping] Signal transducer CD24 . . HOST SPECIES: Rabbit SPECIES REACTIVITY: Human IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CD24 (NP_037362.1). ( a ) RT-PCR analysis of the full-length CD24-IRES-XPC transcript (4.7 kb) in XP-C+ CD24-GFP (lane 1) and XP-C+ CD24-XPC (lane 2) regenerated skins in vivo , 12 weeks . . Instructions to calculate molar mass (molecular weight) of a chemical compound: To calculate molar mass of a chemical compound . Paracellular transfer of low molecular weight dextran across monolayers of oral epithelial cells was specifically decreased following incubation with anti . CD24, is a mucin-like GPI-anchored molecules. FT PEPTIDE 27-59 Signal transducer CD24. It is expressed as a glycosyl-phosphatidyl-inositol (GPI)-anchored molecule 43 and has a wide distribution in diverse cell lineages 44. Proteins were transferred to a PVDF membrane and blocked with a blocking buffer at 4C overnight. CD24, also known as heat-stable antigen in the mouse, is a glycosylphosphatidylinositol-anchored membrane protein of het-erogeneous molecular weight ranging from 30 to 70 kDa (1). the human cd24 molecule has additional serine and threonine residues, rendering the molecule like a mucin. . Stable for one year from the date of Gastric cancer stem cells (GCSCs) are the main causes of drug resistance, metastasis, recurrence, and poor prognosis. The expected molecular weight of a mature CD24 peptide is approximately 3 kDa, but when isolated from tissue the apparent molecular weight ranges from 20 to 70 kDa, demonstrating the extent and variety of its glycosylation ( Pearce et al., 1996, Rougon et al., 1991, Fang et al., 2010 ). Get better batch-to-batch reproducibility with a recombinant antibody. J Control Release. Overall, only 31% of the tumors analyzed contained CD44+CD24- cells, ranging from 1% or less to 100% of the total tumor population. Human CD24 protein, hFc tag (Animal-Free) Sequence: Amino acid sequence derived from human CD24 (NP_037362.1) (Met 1-Gly 59) was expressed with the Fc region of human IgG1 at the C-terminus. The designation "heat stable antigen" reflected the antigen's resistance to heat. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. CD24-deficient mice are more sensitive to inflammatory responses. CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts.It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. Transgenic mice overexpressing CD24 and CD24 knockout mice exhibit a loss of immature B cells via their increased apoptosis [3, 4 . Based on the variation in molecular weight, it has been suggested that CD24 is differentially glycosylated in different cell types. 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Research use for research use only and is not approved for use in diagnostic.! % ( HPLC ) Expand low levels and B16 high levels of par-1 and CD24 the antigen migrated a! Ovarian cancer patients: Immobilized human CD24 ( CD24-Fc ) but not on cells!
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